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Juan XIE,Xinyu ZHANG,Zhiwei XU,Guofu YUAN,Xinzhai TANG,Xiaomin SUN,D.J. BALLANTINE
《环境科学与工程前沿（英文）》 2014年 第8卷 第4期 页码 561-569 doi: 10.1007/s11783-013-0601-5
关键词： Chinese Ecosystem Research Network (CERN) total phosphorus (TP) surface water ecosystem type spatial variation
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 337-346 doi: 10.1007/s11684-014-0349-8
Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recognized and adhered by TCM clinical practitioners for thousands of years. However, the underlying mechanisms of TCM personalized medicine are not fully investigated so far and remained unknown. This paper discusses framework of TCM personalized medicine in classic literatures and in real-world clinical settings, and investigates the underlying mechanisms of TCM personalized medicine from the perspectives of network medicine. Based on 246 well-designed outpatient records on insomnia, by evaluating the personal biases of manifestation observation and preferences of herb prescriptions, we noted significant similarities between each herb prescriptions and symptom similarities between each encounters. To investigate the underlying mechanisms of TCM personalized medicine, we constructed a clinical phenotype network (CPN), in which the clinical phenotype entities like symptoms and diagnoses are presented as nodes and the correlation between these entities as links. This CPN is used to investigate the promiscuous boundary of syndromes and the co-occurrence of symptoms. The small-world topological characteristics are noted in the CPN with high clustering structures, which provide insight on the rationality of TCM personalized diagnosis and treatment. The investigation on this network would help us to gain understanding on the underlying mechanism of TCM personalized medicine and would propose a new perspective for the refinement of the TCM individualized clinical skills.
关键词： personalized medicine complex network clinical phenotype network traditional Chinese medicine
Zhenji Li, Chunbo Xu
《医学前沿（英文）》 2011年 第5卷 第2期 页码 208-211 doi: 10.1007/s11684-011-0126-x
关键词： fundamental theory traditional Chinese medicine research strategy
Clinical research of traditional Chinese medicine in big data era
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 321-327 doi: 10.1007/s11684-014-0370-y
With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named “The Fourth Paradigm,” has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the “causality inference” to “correlativity analysis.” This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine (TCM), and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.
关键词： big data traditional Chinese medicine clinical evaluation evidence based medicine
The stem cell and tissue engineering research in Chinese ophthalmology
GE Jian, LIU Jingbo
《医学前沿（英文）》 2007年 第1卷 第1期 页码 6-10 doi: 10.1007/s11684-007-0002-x
关键词： available observable neuroregeneration protection function reconstruction
CHALLENGES PROVIDING MULTIPLE ECOSYSTEM BENEFITS FOR SUSTAINABLE MANAGED SYSTEMS
《农业科学与工程前沿（英文）》 2022年 第9卷 第2期 页码 170-176 doi: 10.15302/J-FASE-2022444
Since humans started practicing agriculture at the expense of natural forests, 8000 years ago, they have affected atmospheric CO2concentrations. Their impact on atmospheric CH4 started about 5000 years ago, as result of the cultivation of paddy rice. A challenge of modern agricultural practices is to reverse the impact cropping has had on greenhouse gas emissions and the global climate. There is an increasing demand for agriculture to provide food security as well as a range of other ecosystem services. Depending on ecosystem management, different practices may involve trade-offs and synergies, and these must be considered to work toward desirable management systems. Solution toward food security should not only focus on agricultural management practices, but also on strategies to reduce food waste, more socially-just distribution of resources, changes in lifestyle including decarbonization of the economy, as well as reducing human population growth.
关键词： crop diversification / ecosystem services / food security / sustainable cropping systems
Overview of the quality standard research of traditional Chinese medicine
Huimin Gao, Zhimin Wang, Yujuan Li, Zhongzhi Qian
《医学前沿（英文）》 2011年 第5卷 第2期 页码 195-202 doi: 10.1007/s11684-011-0134-x
关键词： traditional Chinese medicine quality standard quality control quantitative analysis of multi-components by single-marker
周红,成虎,徐鹏富
《中国工程科学》 2006年 第8卷 第10期 页码 94-98
依据生态学和应用生态学的基本概念和原理，结合工程项目系统的特征，提出了工程项目生态系统的概念。采用对比分析法对工程项目生态系统的层次结构、原则、组成进行了具体的分析。工程项目生态系统的演化、平衡和生命系统一样，是个非线性的耗散结构,其演化和平衡满足逻辑斯谛模型。
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 300-309 doi: 10.1007/s11684-014-0357-8
The current modes of experience inheritance from famous specialists in traditional Chinese medicine (TCM) include master and disciple, literature review, clinical-epidemiology-based clinical research observation, and analysis and data mining via computer and database technologies. Each mode has its advantages and disadvantages. However, a scientific and instructive experience inheritance mode has not been developed. The advent of the big data era as well as the formation and practice accumulation of the TCM clinical research paradigm in the real world have provided new perspectives, techniques, and methods for inheriting experience from famous TCM specialists. Through continuous exploration and practice, the research group proposes the innovation research mode based on the real-world TCM clinical research paradigm, which involves the inheritance and innovation of the existing modes. This mode is formulated in line with its own development regularity of TCM and is expected to become the main mode of experience inheritance in the clinical field.
关键词： traditional Chinese medicine (TCM) real world clinical research paradigm famous specialist experience inheritance
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《农业科学与工程前沿（英文）》 2019年 第6卷 第4期 页码 313-320 doi: 10.15302/J-FASE-2019282
Phosphate is supplied to agriculture by mining and fertilizer production, followed by different steps of phosphate utilization, including primary production, feed and food consumption, and conversion of biomass, with accumulation in soils, but little recycling and severe environmental losses. Phosphate is a limited essential nutrient, however, with very uneven distribution worldwide. Closing the cycle and reducing primary phosphate consumption are fundamental future challenges. Maize has a relatively high phosphate requirement. China and Germany together cover the whole range of maize production systems. The new Sino-German international research training group “Adaptation of Chinese and German maize-based food-feed-energy systems to limited phosphate resources” (AMAIZE-P) was initiated in 2018 as a joint venture of the China Agricultural University (Beijing, China) and the University of Hohenheim (Stuttgart, Germany). The interdisciplinary and complementary research is driven by the hypothesis that under phosphate limited conditions, high productivity and high phosphate use efficiency can be achieved simultaneously by adapting phosphate cycling and availability (sources) to the multipurpose phosphate demands (sinks) in maize-based food-feed-energy systems. The educational program for doctoral researchers in China and Germany includes joint block seminars, thematic field trips, case studies, methodological courses, doctoral researchers’ conferences, intercultural training sessions and personal training.
关键词： international research training group limited resources maize phosphate
Mechanisms of “kidney governing bones” theory in traditional Chinese medicine
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 389-393 doi: 10.1007/s11684-014-0362-y
Studies conducted by our group on the mechanism of “kidney governing bones” theory in traditional Chinese medicine (TCM) are reviewed in this paper. Conclusions can be summarized as follows. (1) Neuroendocrine-immune network (NIN)-osteoclast regulatory pathway OPG-RANKL-RANK is one of the mechanisms of “kidney governing bones.” Although kidney-reinforcing therapy is regarded as one of the holistic regulatory mechanisms of the body, characteristic holistic regulation in TCM can be reflected through nonselective regulation of the NIN during kidney reinforcement therapy, which can be used to treat osteoporosis through microadjustments in the microenvironment of the bone marrow. (2) Marrow exhaustion in TCM, which is the state wherein lipocytes in the bone marrow increase whereas other cells decrease, serves as the pathogenesis of osteoporosis brought about by failure of the “kidney governing bones.” (3) The kidney in TCM can be regarded as a complex system comprising multiple functional units in the body, including the unit “governing bones.” Kidney deficiency refers to a deficiency in only one or more units of the kidney system and not the whole system itself, which explains the kidney-reinforcing effect of many herbs; some herbs can treat osteoporosis, but some cannot. Although both classified as kidney-reinforcing agents, the former can resolve failure of the “kidney governing bones” unit while the latter regulates the failure of other units in the kidney system. Despite the current understanding on “kidney governing bones” theory, the mechanism of “kidney governing bones” remains complicated and unresolved. Thus, further studies in this area are warranted.
关键词： kidney governing bones kidney deficiency marrow osteoporosis neuroendocrine-immune network osteoclast regulatory pathway
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《农业科学与工程前沿（英文）》 2019年 第6卷 第4期 页码 443-444 doi: 10.15302/J-FASE-2019288
“能源领域咨询研究”综合组
《中国工程科学》 2015年 第17卷 第9期 页码 18-28
目前能源“金三角”正处于发展战略机遇期，大规模的能源开发支持了区域经济快速增长，在我国能源格局中的战略地位举足轻重。本文从该区域能源经济社会发展状况入手，分析阐述了区域发展环境与比较优势，重点分析了区域发展中所面临的产业结构同质化严重、能源资源开发粗放、煤炭转化无序竞争、能源外输压力大、水资源短缺、生态环境脆弱等一系列问题，提出了“统筹规划、科学开发、有序转化、优化输配、多能协同、生态低碳”的发展战略思路，建议重点打造能源“金三角”综合改革试验区，推进区域一体化发展，为促进区域产业转型升级与可持续发展提供参考。
EMERGY analysis for sustainability evaluation of the Baiyangdian wetland ecosystem in China
Weiqing MENG, Cui HAO, Hongyuan LI, Meiting JU,
《环境科学与工程前沿（英文）》 2010年 第4卷 第2期 页码 203-212 doi: 10.1007/s11783-010-0015-6
关键词： EMERGY analysis sustainability wetland ecosystem indicators
标题 作者 时间 类型 操作
Total phosphorus concentrations in surface water of typical agro- and forest ecosystems in China, 2004–2010
Juan XIE,Xinyu ZHANG,Zhiwei XU,Guofu YUAN,Xinzhai TANG,Xiaomin SUN,D.J. BALLANTINE
期刊论文
Clinical phenotype network: the underlying mechanism for personalized diagnosis and treatment of traditionalChinese medicine
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期刊论文
The fundamental theory of traditional Chinese medicine and the consideration in its research strategy
Zhenji Li, Chunbo Xu
期刊论文
Overview of the quality standard research of traditional Chinese medicine
Huimin Gao, Zhimin Wang, Yujuan Li, Zhongzhi Qian
期刊论文
Experience inheritance from famous specialists based on real-world clinical research paradigm of traditionalChinese medicine
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期刊论文
Adaptation of Chinese and German maize-based food-feed-energy systems to limited phosphate resources—anew Sino-German international research training group
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期刊论文
Comments on “Adaptation of Chinese and German maize-based food-feed-energy systems to limited phosphateresources—a new Sino-German international research training group”
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期刊论文
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